PARAMS refmac_wrk FULLPATH /Applications/ccp4-6.2.0/examples/rnase rnase.pdb FULLPATH /Applications/ccp4-6.2.0/examples/rnase rnase18.mtz FULLPATH /Applications/ccp4-6.2.0/examples/rnase rnase.tls FNAT SIGFNAT FreeR_flag 10 TLS 20 BULK True 200 NO True 10.0